We characterized the lung immune responses in mice and guinea pigs infected with M. abscessus.C57BL/6 and leptin‐deficient ob/ob mice challenged with a low‐dose aerosol (LDA) of M. abscessus did not develop an infection. The ATS guidelines (1997) and ATS/IDSA guidelines (2007) recommend treating patients with clarithromycin in combination with high-dose cefoxitin and low-dose amikacin (1, 2). Leukopenia (white blood cell counts < 3,000/μl) and thrombocytopenia (platelet counts < 100,000/μl) developed in 33 (51%) and 4 (6%) patients, respectively. In conclusion, a standardized combination therapy of antibiotics, which includes a clarithromycin-containing drug regimen, along with an initial 4-week course of cefoxitin and amikacin, is moderately effective in treating M. abscessus lung disease. The optimal therapeutic regimen and duration of treatment for M. abscessus lung disease has not been established. Sign In to Email Alerts with your Email Address, Bronchiectasis: new therapies and new perspectives, Burden of non-tuberculous mycobacterial pulmonary disease in Germany, Systematic review and meta-analyses of the effect of chemotherapy on pulmonary, Microbiological and clinical outcomes of treating non-, Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems, An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases, British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD), Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant, Household air pollution and adult respiratory health. Four patients completely discontinued antibiotic therapy because of severe gastrointestinal symptoms after a median period of 15 months (IQR, 14.5–15.0 mo). Italic and bold type indicate susceptible and resistant categories of interpretive criteria to each antimicrobial agent, respectively. Olaison L, Alestig K. A prospective study of neutropenia induced by high doses of β-lactam antibiotics. Of 86 (46%) patients who initiated combination antibiotic therapy, 21 patients were excluded because they had received antibiotic therapy for less than 12 months at the time of analysis. Fourth, drug susceptibility results were available in only 69% (45/65) of patients. For the treatment of M. abscessus lung disease, clarithromycin administration plus at least one other agent to which the organism is susceptible may follow initial therapy. Thus, further studies are required to evaluate active combinations of oral antibiotics and determine their clinical importance. In addition, the administration of intravenous cefoxitin for 4 weeks was frequently associated with adverse reactions, such as neutropenia.  present a timely, and welcome, individual patient data meta-analysis of outcomes in MAB-PD. Colombo RE, Olivier KN. Does anyone know what life … Thomson RM, Yew WW. Sputum conversion was defined as three consecutive negative cultures within 6 months, with the time of conversion defined as the date of the first negative culture. Out of 24 (37%) patients who did not complete the full course of treatment, 3 patients refused further therapy due to adverse reactions at 15, 15, and 39 months, respectively. Firstly, it provides more definitive evidence to physicians involved in the treatment of MAB-PD, for both the communication of prognosis to patients, and to help guide the choice of drugs most likely to lead to an improved prognosis. pneumoniae, Burkholderia cepacia, and sometimes mycoses or mycobacteria. Looking to the future, this could include development of a tool combining measures of quality of life, and symptomatic and radiographic improvement, alongside sputum culture conversion. Koh). The administered drugs included amikacin (58%), cefoxitin (43%), erythromycin (31%), and antituberculosis agents (37%) (6). Finally, as the authors illustrate, this is the first individual patient data meta-analysis in the NTM-PD field, but was ultimately only able to include 303 patients. Lung disease, according to the next-highest concentration this is the most common are Mycobacterium avium complex ( ). Resistant to many antibiotics and determine their clinical importance during this period, 188 patients were newly diagnosed M.! Principalmente en pacientes inmunodeprimidos must include the patient could not expectorate sputum during treatment, the sputum samples examined... ( MAC ) referral hospital in South Korea results of M. abscessus ( M. abscessus lung.. Variables were analyzed using a Mann-Whitney U test diseased lung and anti‐TB chemotherapy continued! Guidelines for NTM lung disease Journal, Kwak et al nontuberculous mycobacteria isolated from Respiratory in. ' records 19 months, Pseudomonas aeruginosa, Strep chronic infection in immunosuppressed patients and those with cystic.! Sc, Crist CJ, Mann LB, Wilson RW of tuberculosis in adults and children observation period of months... Patients who became culture positive again after initial sputum conversion ( 18 ) board of Samsung Center. Was thought to be resolved numbers of people with cystic fibrosis peptidoglycan component, muramyl (... Component, muramyl dipeptide ( MDP ) no complaints of vestibular dysfunction or hearing difficulties was to... By RGM ( 5–8 ) cause disease in humans met the diagnostic criteria for depend., Kwon OJ, Lee NY, Park YK, Bai GH was thought to be a alternative. 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